A mutant mouse line (Mutant-X) is discovered that is defective in generating IgG or IgA antibody responses to immunization with the inactivated influenza A virus vaccine. As a first step in determining the gene responsible for the immunodeficiency, T lymphocytes and B lymphocytes are separately isolated from wild-type or Mutant-X mice and mixtures of cells are transferred into Rag-deficient recipients, which are then immunized with the Influenza A vaccine as shown in Figure. Fourteen days later, serum from the immunized mice is collected, and tested for anti-influenza IgG and IgA antibody titers. The results are shown in Figure : mice is:
A) NEMO
B) CD40-ligand
C) CD40
D) AID
E) TACI

Question

A mutant mouse line (Mutant-X) is discovered that is defective in generating IgG or IgA antibody responses to immunization with the inactivated influenza A virus vaccine. As a first step in determining the gene responsible for the immunodeficiency, T lymphocytes and B lymphocytes are separately isolated from wild-type or Mutant-X mice and mixtures of cells are transferred into Rag-deficient recipients, which are then immunized with the Influenza A vaccine as shown in Figure. Fourteen days later, serum from the immunized mice is collected, and tested for anti-influenza IgG and IgA antibody titers. The results are shown in Figure :  mice is:
A) NEMO 
B) CD40-ligand 
C) CD40 
D) AID 
E) TACI

Quizplus · Accepted Answer

The Answer of A mutant mouse line (Mutant-X) is discovered that is defective in generating IgG or IgA antibody responses to immunization with the inactivated influenza A virus vaccine. As a first step in determining the gene responsible for the immunodeficiency, T lymphocytes and B lymphocytes are separately isolated from wild-type or Mutant-X mice and mixtures of cells are transferred into Rag-deficient recipients, which are then immunized with the Influenza A vaccine as shown in Figure. Fourteen days later, serum from the immunized mice is collected, and tested for anti-influenza IgG and IgA antibody titers. The results are shown in Figure :  mice is:
A) NEMO 
B) CD40-ligand 
C) CD40 
D) AID 
E) TACI

A Mutant Mouse Line (Mutant-X) Is Discovered That Is Defective