A small group of HIV-infected individuals are known as 'elite controllers.' These individuals have HIV viral RNA copy numbers that persistently remain

Question

A small group of HIV-infected individuals are known as 'elite controllers.' These individuals have HIV viral RNA copy numbers that persistently remain <50 copies/ml of plasma. Studies examining the immune response to the virus in these individuals would likely reveal:
A) Increased numbers of virus-specific CD4 and CD8 T cells secreting IFN-$\gamma$ compared to individuals with high viral titers
B) That their T cells lacked expression of CCR5
C) Dramatically increased numbers of NK cells compared to individuals with high HIV titers
D) That they were infected only with the X4 strain of the virus
E) Increased levels of chemokines that bind CCR5 compared to individuals with high HIV titers.

Quizplus · Accepted Answer

Elite controllers are able to control HIV replication without the use of antiretroviral therapy (ART). This suggests that they have a robust immune response to the virus. Studies have shown that these individuals have increased numbers of virus-specific CD4 and CD8 T cells secreting IFN-γ compared to individuals with high viral titers. These cytokines are important in the cellular immune response against viral infections.

B, C, D, and E are unlikely to be correct as there is no evidence to suggest that these characteristics are specific to the immune response of elite controllers.

A Small Group of HIV-Infected Individuals Are Known as 'Elite γ\gammaγ

A Small Group of HIV-Infected Individuals Are Known as 'Elite $\gamma$