CXCR5 is the receptor for the chemokine CXCL13, secreted by follicular stromal cells and follicular dendritic cells in the B cell zones (i.e., lymphoid follicles) of secondary lymphoid organs. A conditional knockout mouse in which CXCR5 was specifically deleted only in T cells would have:

Question

Quizplus · Accepted Answer

CXCR5 is essential for T cell migration to B cell zones and the formation of T-B cell interactions, which are required for T cell-dependent antibody responses. Therefore, a conditional knockout mouse with only T cell-specific CXCR5 deletion would have a defect in T cell-dependent antibody responses.

CXCR5 Is the Receptor for the Chemokine CXCL13, Secreted by Follicular