Effector caspases are activated downstream of both extrinsic and intrinsic pathways of apoptosis. Consequently, cells lacking one or more of these enzymes show defects in apoptosis. An alternative means of eliminating the activity of an effector caspase would be to:
A) Generate a form of the pro-caspase with a mutation in the initiator caspase cleavage site
B) Express a mutant form the caspase that lacked the pro-domain
C) Express a constitutively active form of the initiator caspase
D) Generate a knockout mutation that prevented expression of the Fas receptor
E) Generate a mutation in the proteins required for autophagy

Question

Quizplus · Accepted Answer

Mutating the initiator caspase cleavage site on the pro-caspase would prevent its activation, thereby eliminating the activity of the effector caspase.

Effector Caspases Are Activated Downstream of Both Extrinsic and Intrinsic