Cytotoxic T cells are rapid killers of infected target cells. Within minutes of the interaction of a cytotoxic T cell with a target cell, the program of apoptosis in the target cell is initiated. This rapid activity is a consequence of:
A) The expression and packaging of perforin and granzymes in cytotoxic granules prior to target cell encounter
B) The extremely rapid production of granzymes and perforin by cytotoxic effector cells upon encountering a target cell
C) The extremely potent activity of perforins in poking holes in target cell membranes allowing entry of granzymes
D) The efficient activity of granzymes in cleaving effector caspases leading to direct activation of apoptosis
E) The large number of cytotoxic granules made and secreted by a single effector cytotoxic T cell

Question

Quizplus · Accepted Answer

Cytotoxic T cells store perforin and granzymes in cytotoxic granules before encountering a target cell. The interaction with the target cell stimulates the release of these cytotoxic granules containing perforin and granzymes, leading to the initiation of apoptosis in the target cell within minutes.

Cytotoxic T Cells Are Rapid Killers of Infected Target Cells