Two distinct lineages of T cells can be identified based on their expression of $\alpha$:$\beta$ versus $\gamma$:$\delta$ T-cell receptors. A deficiency in the signaling receptor Notch1 would result in:
A) A loss of $\alpha$:$\beta$ but not $\gamma$:$\delta$ T cells
B) A loss of both of $\alpha$:$\beta$ and $\gamma$:$\delta$ T cells
C) A loss of $\alpha$:$\beta$ T cells and a massive expansion of $\gamma$:$\delta$ T cells
D) An increased number of both of $\alpha$:$\beta$ and $\gamma$:$\delta$ T cells
E) A normal number of both of $\alpha$:$\beta$ and $\gamma$:$\delta$ T cells

Question

Two distinct lineages of T cells can be identified based on their expression of $\alpha$:$\beta$ versus $\gamma$:$\delta$ T-cell receptors. A deficiency in the signaling receptor Notch1 would result in:
A) A loss of $\alpha$:$\beta$ but not $\gamma$:$\delta$  T cells
B) A loss of both of $\alpha$:$\beta$ and $\gamma$:$\delta$  T cells
C) A loss of $\alpha$:$\beta$ T cells and a massive expansion of $\gamma$:$\delta$  T cells
D) An increased number of both of $\alpha$:$\beta$ and $\gamma$:$\delta$  T cells
E) A normal number of both of $\alpha$:$\beta$ and $\gamma$:$\delta$  T cells

Quizplus · Accepted Answer

Notch1 is required for the development of both the αβ and γδ T cell lineages. Thus, a deficiency in Notch1 would result in a loss of both F1F1F1S1αF1F1F10:F1F1F1S1βF1F1F10 and F1F1F1S1γF1F1F10:F1F1F1S1δF1F1F10 T cells.

Two Distinct Lineages of T Cells Can Be Identified Based α\alphaα

Two Distinct Lineages of T Cells Can Be Identified Based $\alpha$