Alloreactivity refers to the ability of T cells to respond to allelic polymorphisms in MHC molecules when mixed with antigen-presenting cells from a genetically different individual. The T-cell receptors involved in alloreactive responses are recognizing amino acid sequences on foreign MHC molecules and do not interact at all with the peptides bound to these MHC molecules.

Question

Quizplus · Accepted Answer

Alloreactivity indeed involves T cell responses to allelic differences in MHC molecules between individuals, but the T-cell receptors can interact both with the foreign MHC molecules themselves and with the peptides bound to these MHC molecules. The recognition is not exclusive to the MHC molecule without regard to the bound peptide.

Alloreactivity Refers to the Ability of T Cells to Respond