NKG2D is an activating receptor expressed on NK cells, $\gamma$:$\delta$ T cells, and some cytotoxic $\alpha$:$\beta$ T cells. When stressed or infected cells up-regulate receptors that bind to and activate NKG2D molecules, the stressed or infected cells will be killed. This pathway relies on the fact that stressed or infected cells up-regulate:
A) All classical MHC class I molecules
B) HLA-C molecules that bind KIRs
C) MHC class Ib genes such as MICA, MICB, and RAET1
D) Qa-1 and HLA-E molecules that bind leader peptides of other HLA class I molecules
E) HLA-G molecules just like those expressed on the fetal-derived cells in the placenta

Question

Quizplus · Accepted Answer

NKG2D is activated by stress-induced ligands, which are predominantly MHC class Ib antigens such as MICA, MICB, and RAET1. Up-regulation of classical MHC class I molecules, HLA-C molecules that bind KIRs, Qa-1 and HLA-E molecules that bind leader peptides of other HLA class I molecules, and HLA-G molecules do not activate NKG2D.

NKG2D Is an Activating Receptor Expressed on NK Cells γ\gammaγ δ\deltaδ

NKG2D Is an Activating Receptor Expressed on NK Cells $\gamma$ $\delta$