The generation of a complete coding sequence for an antibody heavy chain involves a lymphocyte-restricted process of DNA rearrangement that links V, D, and J gene segments together to form the exon that encodes the heavy chain V region. A similar type of DNA rearrangement is also utilized for the simultaneous expression of IgM and IgD antibodies by the same B cell.

Question

Quizplus · Accepted Answer

The simultaneous expression of IgM and IgD antibodies by the same B cell is not due to DNA rearrangement but rather alternative splicing of the primary RNA transcript.

The Generation of a Complete Coding Sequence for an Antibody