When a B cell differentiates into a plasma cell, it goes from expressing membrane-bound IgM to making mostly the secreted form of IgM. A deletion of the first polyadenylation site in the μ heavy chain gene would prevent activated B cells from making the secreted form of IgM.

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The first polyadenylation site in the μ heavy chain gene is responsible for the production of the secreted form of IgM. If it is deleted, B cells would not be able to produce the secreted form of IgM.

When a B Cell Differentiates into a Plasma Cell, It