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Although Homozygous Deficiencies in Complement Regulatory Proteins Cause Serious Diseases

Question 22

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Although homozygous deficiencies in complement regulatory proteins cause serious diseases, more subtle alterations in the balance of complement activation versus inhibition have been found to contribute to disease susceptibility. Describe the genetic evidence linking subtle alterations in complement regulatory proteins to disease susceptibility.

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Two types of genetic alterations in comp...

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