In what type of inhibition can the inhibitor only bind to the ES complex to form an ESI complex?
A) competitive
B) noncompetitive
C) irreversible
D) uncompetitive
E) None of the above.

Question

In what type of inhibition can the inhibitor only bind to the ES complex to form an ESI complex? 
A) competitive
B) noncompetitive
C) irreversible
D) uncompetitive
E) None of the above.

Quizplus · Accepted Answer

In uncompetitive inhibition, the inhibitor can only bind to the ES complex to form an ESI complex. Competitive inhibition involves binding of the inhibitor to the active site of the enzyme, noncompetitive inhibition involves binding to a site other than the active site, and irreversible inhibition involves covalent bonding to the enzyme. Therefore, the best choice is D, uncompetitive inhibition.

In What Type of Inhibition Can the Inhibitor Only Bind