If a newly made polypeptide is to be secreted from a cell, what must occur before it is secreted?

Question

Quizplus · Accepted Answer

The newly made polypeptide must have a signal sequence that targets it to the endoplasmic reticulum (ER) for processing and modification before being transported to the Golgi and eventually secreted from the cell. The signal sequence is a short stretch of amino acids that helps to direct the polypeptide to the appropriate location. Once in the ER, it may undergo further modifications such as folding and glycosylation before being transported to the Golgi. The signal sequence is typically removed by a signal peptidase enzyme before the polypeptide is secreted.

If a Newly Made Polypeptide Is to Be Secreted from a Cell