In receptor-mediated endocytosis, receptor molecules are initially localized on the outer surface of the plasma membrane. Where do the receptors end up following endocytosis?

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Quizplus · Accepted Answer

Following endocytosis, the receptors get internalized into the cell inside a vesicle, which fuses with an early endosome. The early endosome is a sorting compartment that sorts out the receptors from the ligands. The receptors can either return to the plasma membrane or be targeted for degradation to lysosomes, but initially, they end up on the inside surface of the vesicle.

In Receptor-Mediated Endocytosis, Receptor Molecules Are Initially Localized on the Outer