In obese people, leptin levels are high in the blood but low in the cerebrospinal fluid.

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Quizplus · Accepted Answer

This is true. Obesity is characterized by resistance to the hormone leptin, which is produced by adipose tissue (fat) and acts in the brain to regulate appetite and energy expenditure. In obese individuals, leptin levels in the blood are typically high, indicating an excess of fat mass, but leptin levels in the cerebrospinal fluid (which bathes the brain and spinal cord) are low, suggesting a reduced ability of leptin to signal in the brain. This phenomenon is thought to contribute to the development and maintenance of obesity.

In Obese People, Leptin Levels Are High in the Blood