Studies of H.M. and of patients with similar kinds of brain damage have demonstrated that the implicit and explicit memory systems seem to involve different areas of the brain.

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Studies have shown that the implicit and explicit memory systems are associated with different areas of the brain. For example, the hippocampus is involved in explicit memory, while the basal ganglia and cerebellum are involved in implicit memory. Patients with damage to these areas can have different types of memory impairments.