You are a genetic counselor, and a man with the translocation shown in the figure is your client. He and his partner who has a normal karyotype) wish to have children. You explain to him that the probability of having a child with a normal karyotype is

Question

Quizplus · Accepted Answer

By the law of segregation, either chromosome of the first pair may be passed into a gamete with either chromosome of the second pair. Thus, if all four possible gametes that could result are drawn out, there is one possible gamete out of four that would contain both normal chromosomes, so there is a 25% chance of having a child with a normal karyotype.

You Are a Genetic Counselor, and a Man with the Translocation