Lactate is formed and accumulates in the muscle when the rate of glycolytic production of NADH exceeds the rate at which these products are shuttled into the mitochondria.

Question

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Lactate is formed in the muscle when there is an excess of glycolytic production of NADH, which cannot be efficiently shuttled into the mitochondria for oxidative phosphorylation. This leads to an accumulation of lactate in the muscle, resulting in muscle fatigue and discomfort.

Lactate Is Formed and Accumulates in the Muscle When the Rate