Select the events that must occur for inherited retinoblastoma to develop. Check all that apply.

Question

Quizplus · Accepted Answer

Inherited retinoblastoma involves inheriting one mutated copy of the Rb gene and then acquiring a second mutation in the other copy. This loss of Rb function leads to unregulated E2F, allowing the cell to proceed uncontrolled through cell division. Mutation of the p53 gene is not a requirement for retinoblastoma development.

Select the Events That Must Occur for Inherited Retinoblastoma to Develop