Polycomb group (PcG)mutants cause gain-of-function of Antennapedia (Antp)and other homeotic genes by causing some of these genes to be expressed in tissues where they are usually repressed. PcG has a domain that binds to methylated histone H3. This finding supports which of the following hypotheses?
A)that PcG binds to Antp genes and serves as a transcription activator
B)that PcG mutants have phenotypes like those of Antp mutants
C)that PcG regulates genes by altering chromatin remodeling
D)that PcG initiates repression of Antp genes in tissues
E)that PcG is a repressor molecule like those found in bacteria

Question

Quizplus · Accepted Answer

The finding that PcG has a domain that binds to methylated histone H3 supports the hypothesis that PcG regulates genes by altering chromatin remodeling. This suggests that PcG has a role in regulating gene expression by modifying the chromatin structure of target genes, which in turn affects their transcription. This is consistent with the known function of PcG as a gene silencer and repressor, rather than an activator like option A suggests. Options B, D, and E are not supported by the information given in the question stem.

Polycomb Group (PcG)mutants Cause Gain-Of-Function of Antennapedia (Antp)and Other Homeotic