Aniridia is a human condition in which the eye has no iris. The protein encoded by the gene responsible for aniridia is very nearly identical to the protein product of the fly Eyeless protein. What experiment could provide evidence that the two genes are functionally equivalent?
A)Introduce the aniridia mutation into Drosophila embryos to look for iris formation.
B)Sequence the Eyeless and aniridia DNA sequences and regulators.
C)Use the Eyeless mRNA as a probe in other invertebrate and non-mammalian species.
D)Introduce the mouse aniridia wild-type sequence into the fly egg to see whether mouse eyes develop.
E)Introduce the mouse aniridia wild-type sequence into the fly egg to see whether fly eyes develop.

Question

Quizplus · Accepted Answer

Introducing the mouse aniridia wild-type sequence into the fly egg to see whether fly eyes develop would demonstrate functional equivalence, as it would show that the mouse gene can substitute for the fly gene in eye development.

Aniridia Is a Human Condition in Which the Eye Has