Question 1

Caffeine is not an alkaloid.

Accepted Answer

Caffeine is an alkaloid, which is a class of nitrogen-containing compounds found in various plants.

Question 2

Amines with more that six carbon atoms are soluble in water.

Accepted Answer

Amines with more than six carbon atoms are typically nonpolar and therefore not soluble in water, which is a polar solvent.

Question 3

Amines do not form hydrogen bonds.

Accepted Answer

Amines can form hydrogen bonds between their nitrogen atoms and hydrogen atoms in other molecules or in adjacent amine molecules.

Question 4

Ethylmethylamine is a tertiary amine.

Accepted Answer

Ethylmethylamine is a secondary amine, not a tertiary amine.

Question 5

The amine functional group is rarely found in pharmacologically active compounds.

Accepted Answer

The amine functional group is actually very common in pharmacologically active compounds, such as antibiotics, antidepressants, and antihistamines.

Question 6

Amines are mostly ionized in water.

Accepted Answer

Amines are weak bases and only partially ionize in water, meaning that a significant portion of amine molecules remain uncharged in aqueous solution.

Question 7

Atropine and cocaine are used in the diagnosis of eye diseases.

Accepted Answer

Atropine and cocaine are commonly used in ophthalmology to dilate the pupil and aid in the diagnosis of various eye diseases.

Question 8

Pyrimidine derivatives are found in DNA.

Accepted Answer

Pyrimidine derivatives, specifically cytosine and thymine, are two of the four nitrogenous bases found in DNA.

Question 9

Nicotine is a pharmacologically active aromatic amide.

Accepted Answer

Nicotine is a pharmacologically active alkaloid, not an aromatic amide.

Question 10

Ammonium salts are odorless and usually highly water soluble.

Accepted Answer

Ammonium salts are indeed odorless and typically have high water solubility.

Question 11

Amines do not ionize in water.

Accepted Answer

Amines can ionize in water, under certain conditions, in the form of their conjugate acid (NH4+) or conjugate base (NH2-). However, they are weaker bases than ammonia (NH3), and thus less likely to ionize.

Question 12

Crack cocaine is produced by the neutralization and extraction of cocaine from its hydrochloride salt.

Accepted Answer

This is true. Crack cocaine is essentially cocaine that has been processed so that the hydrochloride salt has been removed, leaving a form of cocaine that can be smoked for a faster and more intense high. This process involves neutralization and extraction, as well as additional steps such as heating and cooling the mixture to create the hardened, rock-like substance that is characteristic of crack cocaine.

Question 13

Ammonium salts are usually liquid at room temperature.

Accepted Answer

Ammonium salts are typically solid at room temperature, although there are some exceptions where they can be liquid or even gaseous. It depends on the specific ammonium salt and its physical properties.

Question 14

Hydrogen bonds in amines are weaker than those in alcohols.

Accepted Answer

Amines form hydrogen bonds through nitrogen, which is less electronegative than oxygen in alcohols, resulting in weaker hydrogen bonds.

Question 15

Meperidine is a synthetic compound developed from morphine.

Accepted Answer

Meperidine, also known as Demerol, is a synthetic opioid compound that was originally synthesized as a non-addictive alternative to morphine.

Question 16

Primary amines contain two carbon-containing groups bonded to the nitrogen atom.

Accepted Answer

Primary amines contain only one carbon-containing group bonded to the nitrogen atom. The other two substituents may be hydrogen atoms or alkyl/aryl groups.

Question 17

The compound shown is a tertiary amine.

Accepted Answer

A tertiary amine is defined as an amine in which the nitrogen atom is bonded to three carbon atoms. In the given compound, the nitrogen atom is bonded to three carbon atoms, hence it is a tertiary amine.

Question 18

Amines act as weak acids by accepting protons from water.

Accepted Answer

Amines act as weak bases by donating a pair of electrons to proton (H+) and forming a positively charged ammonium ion. They do not act as weak acids by accepting protons from water.

Question 19

Quinine is an alkaloid used for treatment of malaria.

Accepted Answer

Quinine is indeed an alkaloid used for treatment of malaria.

Question 20

Heterocyclic amines contain a nitrogen atom in a ring.

Accepted Answer

Heterocyclic amines are cyclic organic compounds that contain a nitrogen atom as part of the ring structure. This nitrogen atom can be found in various heterocycles, such as pyridines, pyrimidines, and purines.

Quiz 18: Amines and Amides