Hoogsteen base-pairing occurs when a third strand of DNA binds along the _____ of a double helix of DNA.
A) minor groove
B) major groove
C) free 5'end
D) free 3'end
E) Any of these parts of a DNA double helix could participate in a Hoogsteen interaction.

Question

Quizplus · Accepted Answer

Hoogsteen base-pairing involves the interaction of a third strand of DNA with the major groove of a double helix. This type of base-pairing allows for the formation of triple-stranded structures.

Hoogsteen Base-Pairing Occurs When a Third Strand of DNA Binds