Which statement is TRUE of the binding energy derived from enzyme-substrate interactions?
A) It cannot provide enough energy to explain the large rate accelerations brought about by enzymes.
B) It is sometimes used to hold two substrates in the optimal orientation for reaction.
C) It is the result of covalent bonds formed between enzyme and substrate.
D) Most of it is derived from covalent bonds between enzyme and substrate.
E) Most of it is used up simply binding the substrate to the enzyme.

Question

Quizplus · Accepted Answer

The binding energy derived from enzyme-substrate interactions is sometimes used to hold two substrates in the optimal orientation for reaction. This can contribute to the rate acceleration brought about by enzymes. However, it is not the only factor involved in enzyme activity, and other mechanisms such as transition-state stabilization also play a role. The binding energy is typically not the result of covalent bonds formed between enzyme and substrate, and most of it is not used up simply binding the substrate to the enzyme.

Which Statement Is TRUE of the Binding Energy Derived from Enzyme-Substrate