If you were attempting to design a new drug for the treatment of a disease by interfering with enzyme activity in the disease-causing organism, which type of inhibitor would likely be the MOST effective?
A) a transition-state analog that is an irreversible inhibitor
B) a substrate analog that is a competitive inhibitor
C) a transition-state analog that is a competitive inhibitor
D) a product analog that is an uncompetitive inhibitor
E) a substrate analog that is a mixed inhibitor

Question

Quizplus · Accepted Answer

A transition-state analog that is an irreversible inhibitor would be the most effective type of inhibitor because it would permanently bind to the enzyme and prevent it from functioning. The transition-state analog mimics the transition state of the reaction that the enzyme catalyzes, making it a highly specific inhibitor for that particular enzyme. It is also irreversible, meaning that once it binds to the enzyme, it cannot be easily removed, ensuring a long-lasting effect.

If You Were Attempting to Design a New Drug for the Treatment