Which statement about protein-ligand binding is CORRECT? A) The K_a is equal to the concentration of ligand when all of the binding sites are occupied. B) The K_a is independent of such conditions as salt concentration and pH. C) The larger the K_a (association constant), the weaker the affinity. D) The larger the K_a, the faster is the binding. E) The larger the K_a, the smaller the K_d (dissociation constant).

Question

Quizplus · Accepted Answer

The larger the association constant (indicative of a stronger affinity between the protein and ligand), the smaller the dissociation constant, meaning the ligand is less likely to dissociate from the protein.

Which Statement About Protein-Ligand Binding Is CORRECT