The change in hemoglobin-binding affinity for oxygen due to changing pH and CO₂ concentration in the blood is known as the: A) Hill hypothesis. B) Messelson theory. C) Bohr effect. D) Higgs observation. E) Boyle hypothesis.

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The change in hemoglobin-binding affinity for oxygen due to changing pH and CO₂ concentration in the blood is known as the Bohr effect. The effect was first described by Danish physiologist Christian Bohr in 1904. The effect refers to the fact that as carbon dioxide (CO2) levels increase in the blood, the pH decreases (becoming more acidic), leading to a decrease in hemoglobin's affinity for oxygen. This means that oxygen is more easily released to the body's tissues where it is needed.

The Change in Hemoglobin-Binding Affinity for Oxygen Due to Changing