Which base pair can form a hydrophobic interaction with a protein in the major groove?

Question

Quizplus · Accepted Answer

Both A-T and T-A base pairs can form hydrophobic interactions with proteins in the major groove. This is because the patterns of hydrogen bond donors and acceptors, along with the hydrophobic surfaces presented by the bases, are recognized by proteins. The distinction between A-T and T-A (or G-C and C-G) is related to the directionality of the strands, but both configurations can participate in such interactions.

Which Base Pair Can Form a Hydrophobic Interaction with a Protein