An example of coordinate control is the down-regulation of ribosomal RNA synthesis in response to amino acid starvation, which will cause synthesis of ribosomal proteins to be limited. What is the CORRECT order of the following events that participate in the signaling process?
1. Binding of stringent factor to the ribosome
2. Formation of the unusual nucleotide ppGpp
3. Formation of the unusual nucleotide pppGpp 4. Binding of uncharged tRNA in the ribosomal A-site

Question

Quizplus · Accepted Answer

The correct sequence starts with the binding of uncharged tRNA in the ribosomal A-site, which signals amino acid starvation. This is followed by the binding of stringent factor to the ribosome. The stringent factor then facilitates the formation of the unusual nucleotide pppGpp, which can be further processed into ppGpp. These nucleotides are involved in the down-regulation of ribosomal RNA synthesis, coordinating the cellular response to amino acid starvation.

An Example of Coordinate Control Is the Down-Regulation of Ribosomal