Which Statement About Eukaryotic Versus Prokaryotic Gene Regulation Is NOT

Which statement about eukaryotic versus prokaryotic gene regulation is NOT correct?

A) Access to eukaryotic promoters is restricted by the structure of chromatin.
B) Most regulation is positive, involving activators rather than repressors.
C) Larger and more multimeric proteins are involved in regulation of eukaryotic transcription.
D) Transcription and translation are separated in both space and time.
E) Strong promoters in eukaryotes are generally fully active in the absence of regulatory proteins.