Which combination of cofactors is involved in the conversion of pyruvate to acetyl-CoA?

Question

Quizplus · Accepted Answer

The conversion of pyruvate to acetyl-CoA involves three enzymes: pyruvate dehydrogenase complex (PDC), dihydrolipoyl transacetylase (E2), and dihydrolipoyl dehydrogenase (E3). The cofactors involved in these reactions are thiamine pyrophosphate (TPP) for PDC, lipoic acid for E2, and NAD+ (oxidized form of NAD⁺) for E3. Therefore, the correct combination of cofactors involved in the conversion of pyruvate to acetyl-CoA is TPP, lipoic acid, and NAD⁺.

Which Combination of Cofactors Is Involved in the Conversion of Pyruvate