Which cofactors associated with the pyruvate dehydrogenase complex are classified as prosthetic groups? 1) TPP
2) lipoate
3) CoA-SH
4) NAD⁺
5) FAD

Question

Which cofactors associated with the pyruvate dehydrogenase complex are classified as prosthetic groups? 1) TPP 2) lipoate 3) CoA-SH 4) NAD⁺ 5) FAD

Quizplus · Accepted Answer

Prosthetic groups are non-protein components that are tightly or covalently bound to a protein or enzyme. In the pyruvate dehydrogenase complex, Thiamine pyrophosphate (TPP) and Flavin adenine dinucleotide (FAD) are tightly bound to the enzyme complex, making them prosthetic groups. Lipoate, although not covalently attached to the enzyme, plays a crucial role as a swinging arm for substrate channeling, and is considered a prosthetic group for its essential function and tight association. CoA-SH is a substrate rather than a prosthetic group, and "NAD⁺" appears to be a typographical error and does not represent a known cofactor or prosthetic group.

Which Cofactors Associated with the Pyruvate Dehydrogenase Complex Are Classified