Cellular isozymes of pyruvate kinase are allosterically inhibited by:
A) high concentrations of AMP.
B) high concentrations of ATP.
C) high concentrations of citrate.
D) low concentrations of acetyl-CoA.
E) low concentrations of ATP.

Question

Quizplus · Accepted Answer

Pyruvate kinase, an enzyme involved in glycolysis, is allosterically inhibited by high concentrations of ATP. This inhibition is a regulatory mechanism that slows down glycolysis when the cell's energy levels (ATP levels) are high, indicating that the cell does not need to produce more ATP through glycolysis at that moment.

Cellular Isozymes of Pyruvate Kinase Are Allosterically Inhibited By