Gluconeogenesis must use "bypass reactions" to circumvent three reactions in the glycolytic pathway that are highly exergonic and essentially irreversible. Reactions carried out by which three of the enzymes listed must be bypassed in the gluconeogenic pathway? 1) Hexokinase
2) Phosphoglycerate kinase
3) Phosphofructokinase-1
4) Pyruvate kinase
5) Triosephosphate isomerase
A) 1, 2, 3
B) 1, 2, 4
C) 1, 4, 5
D) 1, 3, 4
E) 2, 3, 4

Question

Quizplus · Accepted Answer

The reactions catalyzed by hexokinase, phosphofructokinase-1, and pyruvate kinase are the three highly exergonic and essentially irreversible steps in glycolysis that must be bypassed in gluconeogenesis.

Gluconeogenesis Must Use "Bypass Reactions" to Circumvent Three Reactions in the Glycolytic