G protein-coupled activation of phospholipase C directly generates which second messenger?
A) diacylglycerol
B) inositol-1,4,5-trisphosphate
C) calcium
D) both diacylglycerol and inositol-1,4,5-trisphosphate
E) both inositol-1,4,5-trisphosphate and calcium

Question

Quizplus · Accepted Answer

G protein-coupled activation of phospholipase C generates both diacylglycerol and inositol-1,4,5-trisphosphate as second messengers. Diacylglycerol remains in the membrane and activates protein kinase C, while inositol-1,4,5-trisphosphate diffuses into the cytoplasm and binds to receptors on the endoplasmic reticulum, leading to the release of calcium ions. So, both diacylglycerol and inositol-1,4,5-trisphosphate act as second messengers in this signaling pathway.

G Protein-Coupled Activation of Phospholipase C Directly Generates Which Second