An enzyme-linked immunosorbent assay (ELISA) with platelet factor 4 (PF4) coated to the surface of microplate wells is used for the diagnosis of:

Question

Quizplus · Accepted Answer

ELISA with PF4 coated to the surface of microplate wells is used for the diagnosis of heparin-induced thrombocytopenia. PF4 forms a complex with heparin, which can be recognized by antibodies in patients who develop heparin-induced thrombocytopenia. ELISA can detect these antibodies and help diagnose the condition. Acute and chronic immune thrombocytopenic purpura are not associated with PF4, and ELISA with PF4 would not be useful for their diagnosis. Aspirin resistance is also not related to PF4 and would not be diagnosed by ELISA with PF4.

An Enzyme-Linked Immunosorbent Assay (ELISA) with Platelet Factor 4 (PF4)