What is the best method for detecting chromosomal material that has been structurally altered?

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Fluorescence in situ hybridization (FISH) is a technique that uses fluorescent probes to bind to specific DNA sequences and visualize their location on the chromosomes. This allows for the detection of chromosomal structural alterations such as deletions, duplications, and translocations. FISH is a sensitive and specific method for detecting these alterations even at a small scale, making it the best method for this purpose. The other options are useful for other applications such as identifying specific regions of a chromosome (G and Q banding) or identifying nucleolar organizer regions (Ag-NOR banding), but they are not as effective at detecting structural alterations.

What Is the Best Method for Detecting Chromosomal Material That