What chromosome abnormality was the first to be identified and associated with a specific malignancy?

Question

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The Philadelphia chromosome, which is a translocation between chromosomes 9 and 22, was the first chromosome abnormality to be associated with a specific malignancy - chronic myeloid leukemia (CML). The discovery of the Philadelphia chromosome in the 1960s by Peter Nowell and David Hungerford paved the way for understanding the genetic basis of cancer and revolutionized cancer therapy with targeted treatments such as imatinib. Trisomy 8 and deletion 7 are commonly seen in various hematologic malignancies, but they were not the first to be identified or associated with a specific cancer. Isocentric chromosome 16 is a rare abnormality seen in some cases of acute myeloid leukemia.

What Chromosome Abnormality Was the First to Be Identified and Associated