An adult female patient from Southeast Asia has no anemia, but her complete blood count (CBC) shows an MCV of 68 fL and marked target cells are observed on her blood film. Cellulose acetate alkaline electrophoresis shows two large bands: approximately 55% migrating with Hb A and 40% migrating with Hb C. What is the patient's most likely genotype?

Question

Quizplus · Accepted Answer

The patient's most likely genotype is Hb A and Hb E, indicated by the presence of a significant amount of Hb A and a band migrating with characteristics similar to Hb C, which is often how Hb E behaves on cellulose acetate alkaline electrophoresis. The Southeast Asian origin and the presence of target cells with a low MCV further support the diagnosis of Hb E trait or disease, as Hb E is prevalent in this region and associated with such hematological findings.

An Adult Female Patient from Southeast Asia Has No Anemia