Which of the following provides a negative feedback for heme synthesis, thus helping to control, by decreasing, its synthesis?

Question

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The concentration of heme in the developing RBC provides a negative feedback for heme synthesis by inhibiting the activity of the enzyme ALAS, which is the rate-limiting enzyme in heme synthesis. When heme concentration is high, it binds to and inhibits ALAS, thus decreasing heme synthesis. This mechanism helps maintain heme concentration within physiological levels. B, C, and D are not directly involved in negative feedback regulation of heme synthesis.

Which of the Following Provides a Negative Feedback for Heme