Many mutations in receptor kinases that lead to cancer allow the receptor to dimerize and become activated, even in the absence of signaling molecules. An example is a mutant form of the EGF receptor kinase called Her2/neu. An antibody that prevents dimerization of Her2/neu receptor kinases is being tested for its effectiveness in preventing cancer. At which stage does this drug work?

Question

Quizplus · Accepted Answer

The antibody that prevents dimerization of Her2/neu receptor kinases would prevent the mutant receptor from becoming activated, even in the absence of signaling molecules, thereby inhibiting the development of cancer. This suggests that the drug works by preventing the receptor from becoming activated, which is represented by Choice C.

Many Mutations in Receptor Kinases That Lead to Cancer Allow