Figure 9.15 shows how normal signaling works with a Ras protein acting downstream of a receptor kinase. You examine a cell line in which Ras is always activated even in the absence of a signaling molecule. This causes constant activation of the kinases in the MAP kinase pathway. Which of the following conditions would be MOST likely to turn off this abnormally active signaling pathway?
A)the addition of a drug that increases the binding affinity of Ras for MAP kinase enzymes in the cytoplasm
B)the addition of a drug that prevents the final kinase from interacting with its target protein in the nucleus
C)the addition of a drug that prevents the dimerization of the receptor kinase
D)the addition of a drug that prevents the phosphorylation of the receptor kinase

Question

Figure 9.15 shows how normal signaling works with a Ras protein acting downstream of a receptor kinase. You examine a cell line in which Ras is always activated even in the absence of a signaling molecule. This causes constant activation of the kinases in the MAP kinase pathway. Which of the following conditions would be MOST likely to turn off this abnormally active signaling pathway? 
A)the addition of a drug that increases the binding affinity of Ras for MAP kinase enzymes in the cytoplasm 
B)the addition of a drug that prevents the final kinase from interacting with its target protein in the nucleus 
C)the addition of a drug that prevents the dimerization of the receptor kinase 
D)the addition of a drug that prevents the phosphorylation of the receptor kinase

Quizplus · Accepted Answer

The Answer of Figure 9.15 shows how normal signaling works with a Ras protein acting downstream of a receptor kinase. You examine a cell line in which Ras is always activated even in the absence of a signaling molecule. This causes constant activation of the kinases in the MAP kinase pathway. Which of the following conditions would be MOST likely to turn off this abnormally active signaling pathway? 
A)the addition of a drug that increases the binding affinity of Ras for MAP kinase enzymes in the cytoplasm 
B)the addition of a drug that prevents the final kinase from interacting with its target protein in the nucleus 
C)the addition of a drug that prevents the dimerization of the receptor kinase 
D)the addition of a drug that prevents the phosphorylation of the receptor kinase

Figure 915 Shows How Normal Signaling Works with a Ras Protein