How do mitogen-activated protein (MAP) kinases become inactive?
A)Ras hydrolyzes GTP to GDP.
B)Ligand diffuses away from the ligand-binding site.
C)Phosphatases remove phosphate groups.
D)Receptor kinases move apart in the membrane.

Question

Quizplus · Accepted Answer

MAP kinases become inactive when phosphatases remove phosphate groups from them. This dephosphorylation decreases their activity by reducing their ability to interact with downstream targets. This is a common mechanism for terminating signaling pathways, as it allows for a rapid shutdown of signaling activity.

How Do Mitogen-Activated Protein (MAP) Kinases Become Inactive