DNP (2,4-dinitrophenol) is an effective weight-loss agent that was used in diet pills in the 1930s. It has since been removed from the market (though it is available online) because of serious side effects such as fever, cataracts, rashes, and sometimes death. DNP inserts into the inner mitochondrial membrane and shuttles protons between the intermembrane space and the matrix. Based on this information, which of the following might you predict?

Question

Quizplus · Accepted Answer

DNP acts as a protonophore, shuttling protons across the mitochondrial membrane, which undermines the proton gradient necessary for ATP synthesis. This leads to reduced ATP production (B), dissipation of the proton gradient (C), and a decreased difference in pH between the matrix and the intermembrane space (E), as the proton gradient is essential for maintaining this pH difference.

DNP (2,4-Dinitrophenol) Is an Effective Weight-Loss Agent That Was Used