Amino acids with hydrophobic side chains are often found in the region of an integral membrane protein that spans the membrane.

Question

Quizplus · Accepted Answer

Hydrophobic side chains repel water molecules and are more compatible with the nonpolar environment of the membrane interior. Integral membrane proteins need to span the entire membrane and therefore the region that interacts with the hydrophobic environment of the membrane is enriched in hydrophobic amino acids.

Amino Acids with Hydrophobic Side Chains Are Often Found in the Region