A single molecule is always either hydrophobic or hydrophilic, and can never possess (at the same time) a region that is hydrophobic and a region that is hydrophilic.

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It is possible for a single molecule to have regions that are both hydrophobic and hydrophilic. These are called amphipathic molecules, and they have a region of the molecule that is attracted to water (hydrophilic) and a region that is repelled by water (hydrophobic). Examples of amphipathic molecules include phospholipids, which make up the cell membrane.

A Single Molecule Is Always Either Hydrophobic or Hydrophilic, and Can