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A Young Man Wants to Determine If He Is a Descendant

Question 185

Multiple Choice

A young man wants to determine if he is a descendant of Henry of Navarre and Eleanor of Aquitaine-two of his favorite historical characters. He sends a cheek swab to a DTC company and is offered a choice (due to funding) : The company can assess either the sequence of the man's Y chromosome or his mitochondrial DNA. Which should he choose?


A) He should get his Y chromosome haplotype sequenced, given the robust genetic variation observed across Y chromosomes.
B) He should get his mitochondrial haplotype sequenced, given the genetic variation in mitochondrial sequences compared to Y chromosomes.
C) It doesn't matter-an equal amount of genetic variation exists between different Y chromosome haplotypes and different mitochondrial haplotypes.

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