When a Chromosome Has Either a Duplication or a Deletion

When a chromosome has either a duplication or a deletion, the chances that the mutation will be harmful are a function of:

A) its size-the smaller the duplication or deletion, the greater the chance of harm.
B) its size-the larger the duplication or deletion, the greater the chance of harm.
C) its location-if it occurs in a germ-line cell, it will be more harmful than if it occurs in a somatic cell.
D) its position on the chromosome-if it occurs at the tip of a long arm, it is likely to be less harmful than if it occurs at the tip of a short arm.
E) None of the other answer options is correct.