In the sickle-cell anemia mutation, the 5'-GAG-3' codon for glutamic acid becomes the 5'-GUG-3' codon for valine. Assuming a single nucleotide substitution accounts for this mutation, what is the change in the DNA?

Question

Quizplus · Accepted Answer

The mutation in sickle-cell anemia involves a change from glutamic acid (GAG in mRNA) to valine (GUG in mRNA). The corresponding DNA change for GAG (coding for glutamic acid) is CTC, and for GUG (coding for valine) is CAC. The correct answer involves changing the second nucleotide from T to A in the DNA sequence, which corresponds to the change from GAG to GUG in the mRNA.

In the Sickle-Cell Anemia Mutation, the 5'-GAG-3' Codon for Glutamic