In organisms with large genomes, inversions are more likely to be tolerated if the breakpoints occur in:

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Quizplus · Accepted Answer

Noncoding DNA is less likely to affect the organism's phenotype, making inversions in noncoding regions more easily tolerated. In contrast, inversions in coding regions or open reading frames can disrupt gene function, gene regulation, and protein structure, potentially leading to deleterious effects. Closed reading frames, also known as pseudogenes, do not contribute to the phenotype and are unlikely to be affected by inversions. Reciprocal translocations are not inversions and involve the exchange of genetic material between non-homologous chromosomes, which can also have deleterious effects.

In Organisms with Large Genomes, Inversions Are More Likely to Be